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KMID : 0438219790160020377
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Korea University Medical Journal
1979 Volume.16 No. 2 p.377 ~ p.384
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The Effect of Morphine on the Metabolism of Norepinephrine
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Abstract
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Numerous studies using a variety of species implicated brain catecholamin in the analgesic activity of morphine. Yet the ability of single doses of morphine to change brain norepirephrine level would appear to be a species dependent phenomenon.
This study was performed to observe the effect of morphine on the content and turnover of norepinephrine(NE) in the brain, heart and kidney of rabbits.
The results were obtained as follows-,
1. Various doses (5, 10 and 20mg/kg) of morphine increased the brain NE and renal NE content and decreased the cardiac NE content 20 minutes after the morphine injection, and these NE changing effects of morphine were dose-dependent.
2. The time courses (20,60 and 90 min.) of the effect of morphine (10 and 20mg/kg) on the NE content in several organs of rabbits showed an initial increase in the brain NE con-tent, acute decrease in the cardiac NE content and gradual increase in the renal NE content.
3. The initial increase of brain NE content induced by morphine was continuously increased by iproniazid pretreatment, but the decreased cardiac NE and increased renal NE content induced by morphine were inhibited by the pretreatment.
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